Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p148 | Cell biology: osteoblasts and bone formation | ECTS2016

Cationic nacre ethanol soluble matrix has an osteoanabolic effect on human subchondral osteoarthritic osteoblasts and MC3T3-E1 cell line

Zhang Ganggang , Brion Alice , Piet Marie-Helene , Moby Vanessa , Bianchi Arnaud , Mainard Didier , Galois Laurent , Aubriet Frederic , Carre Vincent , Gillet Pierre , Rousseau Marthe

Nacre is able to induce bone-forming cells mineralization, and gains widespread interest in bone regeneration. While, the osteoinductive compounds are not identified yet. The nacre extract, ethanol soluble matrix (ESM), was proven having the capacity to induce the mineralization of mouse MC3T3-E1 cells and to restore mineralization defect in human osteoarthritic osteoblasts. Being tested on the two cells, ESM could induce the formation of mineralization nodules, identified as ...